Schmerz, ache, aches and pains, afflict, agitate, angst, anguish, anxiety, bitterness, bleakness, boredom, bother, burden, care, cheerlessness, comfortlessness, depression, difficulty, discomposure, discontent, dislike, dismalness, dismay, displeasure, disquiet, dissatisfaction, distress, distressfulness, disturb, dolor, dread, dreariness, dullness, emptiness, ennui, existential woe, flatness, grief, grieve, grievousness, grimness, hardship, hurt, hurting, inconvenience, inquietude, irritation, joylessness, lack of pleasure, lament, lamentability, lamentation, load with care, malaise, misery, mourn, mournfulness, nausea, nongratification, nonsatisfaction, nuisance, pain, painfulness, pathos, perturb, pitiability, pitiableness, pitifulness, poignancy, put to it, regrettableness, sadness, savorlessness, sharpness, soreness, sorrow, sorrowfulness, spleen, staleness, suffering, tastelessness, tediousness, tedium, trouble, twinge, uncomfortableness, unease, uneasiness, unhappiness, unpleasure, unsatisfaction, upset, vexation, vexation of spirit, woebegoneness, woefulness, worry