accident, adversity, affliction, bane, blow, bugbear, burden, casualty, cataclysm, catastrophe, collapse, collision, contretemps, crack-up, crash, cross, crushing burden, curse, death, desolation, destruction, devastation, disaster, disease, distress, evil, fatal accident, fatality, grief, grievance, hardship, harm, ill hap, infliction, misadventure, mischance, misery, misfortune, mishap, nasty blow, nemesis, open wound, pest, pestilence, pileup, plague, reverse, ruin, ruination, running sore, scourge, shipwreck, shock, smash, smashup, staggering blow, thorn, torment, tragedy, trial, tribulation, trouble, vexation, violent death, visitation, woe, wreck, wretchedness