aching heart, affliction, agony, agony of mind, anguish, bale, bitterness, bleeding heart, broken heart, brokenheartedness, care, crushing, depression, depth of misery, desolation, despair, dole, extremity, grief, heartbreak, heartbrokenness, heartsickness, heartsoreness, heavy heart, infelicity, melancholia, melancholy, misery, prostration, regret, rue, sadness, suicidal despair, woe, wretchedness