acute, afflictive, agonizing, atrocious, baleful, baneful, biting, corroding, corrosive, corrupting, corruptive, counterproductive, cramping, cruel, cutting, damaging, deadly, deleterious, destructive, detrimental, disadvantageous, disserviceable, distressing, excruciating, gnawing, grave, griping, hard, harmful, harrowing, harsh, hurting, injurious, lethal, malefic, malevolent, malicious, malign, malignant, mean, mischievous, nasty, noisome, noxious, ominous, painful, paroxysmal, pernicious, piercing, poignant, poisonous, prejudicial, pungent, racking, scatheful, severe, sharp, shooting, spasmatic, spasmic, spasmodic, spiteful, stabbing, stinging, tormenting, torturous, toxic, unkind, venenate, veneniferous, venenous, venomous, vicious, virulent, wounding