aggravation, annoyance, ass, bad news, bedevilment, besetment, bore, bother, botheration, bothersomeness, burden, buttonholer, crashing bore, devilment, difficulty, dogging, downer, drag, drip, dryasdust, dusty, exasperation, flat tire, frightful bore, harassment, harrying, hassle, headache, hounding, humdrum, inconvenience, irritant, irritation, molestation, nag, ordeal, persecution, pest, pester, pesterer, pill, plague, problem, proser, tease, tormenter, tormentor, trial, trouble, twaddler, vexation, vexatiousness, wet blanket, worriment, worry