Tribulation

(n.) That which occasions distress, trouble, or vexation; severe affliction.

Thesaurus Entries

adverse circumstances, adversity, affliction, aggravation, annoyance, blight, bummer, calvary, care, cross, crucible, curse, difficulties, difficulty, downer, fiery ordeal, hard knocks, hard life, hard lot, hardcase, hardship, irritation, oppression, ordeal, persecution, plight, predicament, pressure, rigor, sea of troubles, stress, stress of life, trial, trials and tribulations, trouble, troubles, vale of tears, vicissitude, visitation